TUNABLE DRUG RELEASE RATE USING MODULAR ORAL DOSAGE FORMS

Oral dosage forms with adjustable drug release profiles were prepared using progesterone (PGR) as a poorly-soluble model drug.The dosage forms were made as stack assemblies of functional modules.The modules were made as PGR-carrying HPMC films cut into wafer-like circular pieces.Two types of modules were used in the study; one exhibited comparative

Positional isomers of hexadecenoic aud octadecenoic acids of human adipose tissue have been separated by gas-liquid chromatography and their amounts determined by oxidative cleavage (MnO4 and IO4).The following isomeric octadecenoic acids were present: 7-octadecenoic acid (0.4%), 8- (1.9%), 9- (73.0%), 10- (2.5%), 11- (19.0%) and 12- (3.2%).The hex